Double Dose Blister Pack

Customised blister packing machinery which actively mixes two ingredients as they are squeezed out of the blister.

Rohrer have been working on a unit dose blister pack with a twist. It is common to have unit dose blister packs with a variety of opening methods. (for example, the Swiss machinery company is just delivering a blister line with robotic loading of unit dose blister with a biologic unit pack.) There are even systems with two forms with different products which are opened together and applied or taken at the same time. But Rohrer’s innovation is to design a blister which actively mixes the two ingredients as they are squeezed out of the blister. This is thought to be a unique system in disposable unit packs. Such a double blister with active mixing is thought to be applicable in such fields as combination drug therapies, drugs which cannot be mixed in transit, animal health applications and novel cosmetic disposable single use packs.

cGMP Filling Machines for Liquid Eyedrops and Biologics

Harro Hofliger have just shipped a special purpose filling machine for dosing and sealing heat sensitive biologics into plastic unit dose tube like containers under aseptic conditions.

Harro Hofliger have just shipped a machine for aseptic filling of liquid eyedrops and biologics into plastic unit dose tube like containers.
As is common with highly potent biotech drugs, a very precise fill volume was critical. Additionally, because of the heat sensitivity of the biologic API, HH used their advanced sealing technology to prevent heating of the liquid during the sealing process. The wall thickness of the final plastic device was critical for the stability of the drug formulation and the machine design had to ensure that this was not compromised during the filling and sealing process Machine design was of course suitable for aseptic filling in cGMP clean room.