cGMP Filling Machines for Liquid Eyedrops and Biologics

Harro Hofliger have just shipped a special purpose filling machine for dosing and sealing heat sensitive biologics into plastic unit dose tube like containers under aseptic conditions.

Harro Hofliger have just shipped a machine for aseptic filling of liquid eyedrops and biologics into plastic unit dose tube like containers.
As is common with highly potent biotech drugs, a very precise fill volume was critical. Additionally, because of the heat sensitivity of the biologic API, HH used their advanced sealing technology to prevent heating of the liquid during the sealing process. The wall thickness of the final plastic device was critical for the stability of the drug formulation and the machine design had to ensure that this was not compromised during the filling and sealing process Machine design was of course suitable for aseptic filling in cGMP clean room.